Issue 3, 2015
From the journal:

RSC Advances

Miniolins A–C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum†

Hao-Yu Tang,‡a   Qiang Zhang,‡a   Yu-Qi Gao,a   An-Ling Zhanga  and  Jin-Ming Gao*a  

* Corresponding authors

a College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China
E-mail: jinminggao@nwsuaf.edu.cn

Abstract

Cultivation of Penicillium minioluteum with azacitidine, a DNA methyltransferase inhibitor, led to the isolation of a novel type of aspertetronin dimer, named miniolins A–C (1–3), along with their precursor aspertetronin A (4). The structures of 1–3 were elucidated by extensive spectroscopic methods, and the absolute configurations were assigned by the chiral HPLC analysis of chemical degradation products and electronic circular dichroism associated with the TDDFT computational method (CAM-B3LYP/TZVP). The miniolins showed moderate cytotoxic activity against Hela cell lines.

Graphical abstract: Miniolins A–C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum

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Article information

DOI
https://doi.org/10.1039/C4RA11712C
Article type
Paper
Submitted
03 Oct 2014
Accepted
13 Nov 2014
First published
18 Nov 2014

RSC Adv., 2015,5, 2185-2190

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Miniolins A–C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum

H. Tang, Q. Zhang, Y. Gao, A. Zhang and J. Gao, RSC Adv., 2015, 5, 2185 DOI: 10.1039/C4RA11712C

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