Issue 96, 2014
From the journal:

RSC Advances

Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala†

Kai-Bo Wang,a   Chun-Mao Yuan,b   Chun-Mei Xue,a   Da-Hong Li,a   Yong-Kui Jing,c   Hong-Ping He,b   Xiao-Jiang Hao,b   Ying-Tong Di,*b   Zhan-Lin Li*a  and  Hui-Ming Hua*a  

* Corresponding authors

a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
E-mail: huimhua@163.com, lzl1030@hotmail.com
Tel: +86-24-23986465/+86-24-23986488

b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China
E-mail: diyt@mail.kib.ac.cn

c Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA

Abstract

Pegaharmalines A (1) and B (2), two novel β-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 μM, respectively.

Graphical abstract: Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala

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Article information

DOI
https://doi.org/10.1039/C4RA07985J
Article type
Communication
Submitted
01 Aug 2014
Accepted
15 Oct 2014
First published
16 Oct 2014

RSC Adv., 2014,4, 53725-53729

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Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala

K. Wang, C. Yuan, C. Xue, D. Li, Y. Jing, H. He, X. Hao, Y. Di, Z. Li and H. Hua, RSC Adv., 2014, 4, 53725 DOI: 10.1039/C4RA07985J

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