Issue 48, 2014
From the journal:

Organic & Biomolecular Chemistry

Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones†

Buddhadeb Mondala  and  Subhas Chandra Pan*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India
E-mail: span@iitg.ernet.in
Fax: +91-361-2582349
Tel: +91-361-2583304

Abstract

Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild reaction conditions.

Graphical abstract: Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones

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Article information

DOI
https://doi.org/10.1039/C4OB02146K
Article type
Communication
Submitted
08 Oct 2014
Accepted
24 Oct 2014
First published
24 Oct 2014

Org. Biomol. Chem., 2014,12, 9789-9792

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Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones

B. Mondal and S. C. Pan, Org. Biomol. Chem., 2014, 12, 9789 DOI: 10.1039/C4OB02146K

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