Issue 80, 2014
From the journal:

Chemical Communications

The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern†

Wei Ting David Lin,a   Po-Jung Jimmy Huang,a   Rachel Pautlera  and  Juewen Liu*a  

* Corresponding authors

a Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada
E-mail: liujw@uwaterloo.ca
Fax: +1 519 746 0435
Tel: +1 519 888 4567 ext. 38919

Abstract

Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.

Graphical abstract: The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC05551A
Article type
Communication
Submitted
18 Jul 2014
Accepted
12 Aug 2014
First published
12 Aug 2014

Chem. Commun., 2014,50, 11859-11862

Permissions

Request permissions

The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern

W. T. D. Lin, P. J. Huang, R. Pautler and J. Liu, Chem. Commun., 2014, 50, 11859 DOI: 10.1039/C4CC05551A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements