Issue 70, 2014
From the journal:

Chemical Communications

Proteolytic stability of amphipathic peptide hydrogels composed of self-assembled pleated β-sheet or coassembled rippled β-sheet fibrils†

Ria J. Swanekamp,a   Jade J. Welcha  and  Bradley L. Nilsson*a  

* Corresponding authors

a Department of Chemistry, University of Rochester, Rochester, NY, USA
E-mail: nilsson@chem.rochester.edu
Fax: +1-585-276-0205
Tel: +1-585-276-3053

Abstract

Hydrogel networks composed of rippled β-sheet fibrils of coassembled D- and L-Ac-(FKFE)2-NH2 amphipathic peptides exhibit proteolytic stability and increased rheological strength compared to networks of self-assembled L-Ac-(FKFE)2-NH2 pleated β-sheet fibrils. Modifying the ratios of L and D peptides in the coassembled rippled β-sheet fibrils alters the degradation profiles of these hydrogel networks.

Graphical abstract: Proteolytic stability of amphipathic peptide hydrogels composed of self-assembled pleated β-sheet or coassembled rippled β-sheet fibrils

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Article information

DOI
https://doi.org/10.1039/C4CC04644G
Article type
Communication
Submitted
18 Jun 2014
Accepted
14 Jul 2014
First published
15 Jul 2014

Chem. Commun., 2014,50, 10133-10136

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Proteolytic stability of amphipathic peptide hydrogels composed of self-assembled pleated β-sheet or coassembled rippled β-sheet fibrils

R. J. Swanekamp, J. J. Welch and B. L. Nilsson, Chem. Commun., 2014, 50, 10133 DOI: 10.1039/C4CC04644G

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