Issue 7, 2014
From the journal:

Biomaterials Science

Application of biomaterials for the detection of amyloid aggregates

Tamotsu Zako*a  and  Mizuo Maedaa  

* Corresponding authors

a Bioengineering Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: zako@riken.jp

Abstract

Amyloid aggregates, which include oligomers and fibrils, are considered to cause various diseases, and their detection is important. In this minireview, recent developments on biomaterials, such as proteins, nanoparticles, and chemical reagents, for detecting amyloid aggregates are discussed. In particular, the molecular chaperone prefoldin (PFD) exhibits interesting properties for the interaction and detection of amyloid oligomers. In fact, any molecule that can bind amyloid aggregates could be useful for their detection.

Graphical abstract: Application of biomaterials for the detection of amyloid aggregates

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Article information

DOI
https://doi.org/10.1039/C4BM00026A
Article type
Minireview
Submitted
23 Jan 2014
Accepted
17 Mar 2014
First published
15 Apr 2014

Biomater. Sci., 2014,2, 951-955

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Application of biomaterials for the detection of amyloid aggregates

T. Zako and M. Maeda, Biomater. Sci., 2014, 2, 951 DOI: 10.1039/C4BM00026A

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