Issue 36, 2014

Fast separation and determination of erythromycin with magnetic imprinted solid extraction coupled with high performance liquid chromatography

Abstract

In this paper a novel composite imprinted material based on poly(methyl methacrylate) (PMMA) coated magnetic multi-walled carbon nanotubes was successfully synthesized using erythromycin as the template and methacrylic acid as the functional monomer. The magnetic carbon nanotube molecularly imprinted polymers (mag-MWCNTs-MIPs) were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and vibrating sample magnetometery (VSM) in detail. The results showed that a magnetic imprinted layer was coated steadily on the surface of the multi-walled carbon nanotubes. Experiments of adsorption dynamics, static adsorption and selective recognition were conducted to evaluate the adsorption performance. The results showed that the mag-MWCNTs-MIPs displayed rapid dynamic adsorption toward erythromycin, which only needed 30 min to achieve adsorption equilibrium with a maximum adsorption capacity of 31.07 mg gāˆ’1. The mag-MWCNTs-MIPs were applied, coupled with high performance liquid chromatography (HPLC), to quickly enrich and detect erythromycin from fish tissue samples with recoveries of 82.7ā€“88.5%. The mag-MWCNTs-MIPs can not only be collected and separated quickly and easily by an external magnet, but also have outstanding mechanical properties and specific recognition toward erythromycin.

Graphical abstract: Fast separation and determination of erythromycin with magnetic imprinted solid extraction coupled with high performance liquid chromatography

Supplementary files

Article information

Article type
Paper
Submitted
03 Dec 2013
Accepted
19 Feb 2014
First published
17 Apr 2014

RSC Adv., 2014,4, 18503-18511

Fast separation and determination of erythromycin with magnetic imprinted solid extraction coupled with high performance liquid chromatography

W. Rao, R. Cai, Z. Zhang, Y. Yin, F. Long and X. Fu, RSC Adv., 2014, 4, 18503 DOI: 10.1039/C3RA47249C

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