Issue 19, 2014
From the journal:

Organic & Biomolecular Chemistry

Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

Daniela Gamenara*a  and  Pablo Domínguez de María†*b  

* Corresponding authors

a Organic Chemistry Department, Universidad de la República (UdelaR), Gral. Flores 2124, 11800 Montevideo, Uruguay
E-mail: dgamenar@fq.edu.uy
Fax: +598 29241906
Tel: +598 29247881

b Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany
E-mail: dominguez@itmc.rwth-aachen.de, dominguez@sustainable-momentum.net
Tel: +34 609 565237

Abstract

Adding value to organic synthesis. Novel imine reductases enable the enantioselective reduction of imines to afford optically active amines. Likewise, novel bioinspired artificial metalloenzymes can perform the same reaction as well. Emerging proof-of-concepts are herein discussed.

Graphical abstract: Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

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Article information

DOI
https://doi.org/10.1039/C3OB42205D
Article type
Review Article
Submitted
07 Nov 2013
Accepted
24 Feb 2014
First published
24 Feb 2014

Org. Biomol. Chem., 2014,12, 2989-2992

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Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

D. Gamenara and P. Domínguez de María, Org. Biomol. Chem., 2014, 12, 2989 DOI: 10.1039/C3OB42205D

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