A novel 99mTc labelling strategy for the development of silica based particles for medical applications

Michel A. Wuillemin; Wanda T. Stuber; Thomas Fox; Michael J. Reber; Dominik Brühwiler; Roger Alberto; Henrik Braband

doi:10.1039/C3DT53019A

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A novel ^99mTc labelling strategy for the development of silica based particles for medical applications†

Michel A. Wuillemin,^a Wanda T. Stuber,^a Thomas Fox,^a Michael J. Reber,^b Dominik Brühwiler,^b Roger Alberto^a and Henrik Braband*^a

Author affiliations

* Corresponding authors

^a Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
E-mail: braband@aci.uzh.ch

^b Institute of Chemistry and Biological Chemistry, Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland

Abstract

The reaction of high-valent fac-{^99mTcO₃}⁺ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

This article is part of the themed collection: New Talent: Europe

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Article information

DOI: https://doi.org/10.1039/C3DT53019A
Article type: Communication
Submitted: 25 Oct 2013
Accepted: 02 Dec 2013
First published: 02 Dec 2013

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Dalton Trans., 2014,43, 4260-4263

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A novel ^99mTc labelling strategy for the development of silica based particles for medical applications

M. A. Wuillemin, W. T. Stuber, T. Fox, M. J. Reber, D. Brühwiler, R. Alberto and H. Braband, Dalton Trans., 2014, 43, 4260 DOI: 10.1039/C3DT53019A

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Dalton Transactions