Issue 75, 2013

Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

Abstract

A new method for the synthesis of N-substituted isoindolinones and 3-arylaminophthalides was developed through aza-Wittig/cyclisation. The reaction of o-phthalaldehydic acid methyl ester with benzylic, aromatic and aliphatic azides gave N-isoindolinones whereas reaction of o-phthalaldehydic acid with the aromatic azides gave 3-arylaminophthalides.

Graphical abstract: Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2013
Accepted
05 Aug 2013
First published
06 Aug 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 8407-8409

Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

S. K. Mamidyala and M. A. Cooper, Chem. Commun., 2013, 49, 8407 DOI: 10.1039/C3CC43838D

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