Issue 15, 2013

Detection of sub-femtomolar DNA based on double potential electrodeposition of electrocatalytic platinum nanoparticles

Abstract

Suspensions of electrocatalytic platinum nanoparticles with radii as small as 78.9 ± 3.5 nm that are functionalised with DNA only in one region have been created using templated electrodeposition. The integrity of the bound DNA following nanoparticle desorption from the electrode is demonstrated by detecting attomolar concentrations of DNA without the need for molecular, e.g., PCR or NASBA, amplification. Double potential step approaches coupled with interface engineering via nucleation sites allows PtNPs to be created with controlled particle size and density in a facile and reproducible manner.

Graphical abstract: Detection of sub-femtomolar DNA based on double potential electrodeposition of electrocatalytic platinum nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
12 Mar 2013
Accepted
22 May 2013
First published
22 May 2013

Analyst, 2013,138, 4340-4344

Detection of sub-femtomolar DNA based on double potential electrodeposition of electrocatalytic platinum nanoparticles

E. Spain, H. McArdle, T. E. Keyes and R. J. Forster, Analyst, 2013, 138, 4340 DOI: 10.1039/C3AN00500C

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