Issue 17, 1981
From the journal:

Journal of the Chemical Society, Chemical Communications

Direct 1H n.m.r. observation of the cell-free conversion of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and δ-(L-α-aminoadipyl)-L-cysteinyl-D-(–)-isoleucine into penicillins

Gulam Bahadur,   Jack E. Baldwin,   Leslie D. Field,   Eeva-M. M. Lehtonen,   John J. Usher,   Carlos A. Vallejo,   Edward P. Abraham  and  Robert L. White  

Abstract

The cell-free conversion of δ-(L-aminoadipyl)-L-cysteinyl-D-(–)-isoleucine (lb) into a penicillin (2b) was observed directly by 1H n.m.r. spectroscopy and the thiazolidine ring formation was shown to occur with retention of stereochemistry at C-3 of the isoleucinyl residue by 1H nuclear Overhauser enhancement studies of the product penicillin in the deproteinated incubation mixture.

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Article information

DOI
https://doi.org/10.1039/C39810000917
Article type
Paper

J. Chem. Soc., Chem. Commun., 1981, 917-919

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Direct 1H n.m.r. observation of the cell-free conversion of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and δ-(L-α-aminoadipyl)-L-cysteinyl-D-(–)-isoleucine into penicillins

G. Bahadur, J. E. Baldwin, L. D. Field, Eeva-M. M. Lehtonen, J. J. Usher, C. A. Vallejo, E. P. Abraham and R. L. White, J. Chem. Soc., Chem. Commun., 1981, 917 DOI: 10.1039/C39810000917

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