Issue 20, 2012
From the journal:

Organic & Biomolecular Chemistry

Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes†

Yusuke Sato,a   Yushuang Zhang,a   Takehiro Seino,a   Takashi Sugimoto,a   Seiichi Nishizawaa  and  Norio Teramae*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan
E-mail: teramae@m.tains.tohoku.ac.jp
Fax: +81-22-795-6552
Tel: +81-22-795-6549

Abstract

We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

Graphical abstract: Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

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Article information

DOI
https://doi.org/10.1039/C2OB25513H
Article type
Communication
Submitted
09 Mar 2012
Accepted
10 Apr 2012
First published
13 Apr 2012

Org. Biomol. Chem., 2012,10, 4003-4006

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Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Y. Sato, Y. Zhang, T. Seino, T. Sugimoto, S. Nishizawa and N. Teramae, Org. Biomol. Chem., 2012, 10, 4003 DOI: 10.1039/C2OB25513H

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