Issue 10, 2012
From the journal:

Chemical Society Reviews

Nitric oxide release: Part I. Macromolecular scaffolds

Daniel A. Riccioa  and  Mark H. Schoenfisch*a  

* Corresponding authors

a Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill
E-mail: schoenfisch@unc.edu

Abstract

The roles of nitric oxide (NO) in physiology and pathophysiology merit the use of NO as a therapeutic for certain biomedical applications. Unfortunately, limited NO payloads, too rapid NO release, and the lack of targeted NO delivery have hindered the clinical utility of NO gas and low molecular weight NO donor compounds. A wide-variety of NO-releasing macromolecular scaffolds has thus been developed to improve NO's pharmacological potential. In this tutorial review, we provide an overview of the most promising NO release scaffolds including protein, organic, inorganic, and hybrid organic-inorganic systems. The NO release vehicles selected for discussion were chosen based on their enhanced NO storage, tunable NO release characteristics, and potential as therapeutics.

Graphical abstract: Nitric oxide release: Part I. Macromolecular scaffolds

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Article information

DOI
https://doi.org/10.1039/C2CS15272J
Article type
Tutorial Review
Submitted
27 Sep 2011
First published
24 Feb 2012

Chem. Soc. Rev., 2012,41, 3731-3741

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Nitric oxide release: Part I. Macromolecular scaffolds

D. A. Riccio and M. H. Schoenfisch, Chem. Soc. Rev., 2012, 41, 3731 DOI: 10.1039/C2CS15272J

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