Issue 21, 2011
From the journal:

CrystEngComm

A hydrogen bonded cocrystal with an unusual interweaving between the adjacent triple-helices†

Amit Deloria  and  William Jones*a  

* Corresponding authors

a Department of Chemistry, Pfizer Institute for Pharmaceutical Materials Science, University of Cambridge, Cambridge, United Kingdom
E-mail: wj10@cam.ac.uk
Fax: +44 1223 336 017
Tel: +44 1223 336 468

Abstract

The structure of a cocrystal between trimethoprim and 2-aminoterephthalic acid has revealed the formation of 3D-interpenetrated networks. Each network is composed of tubular columns, sharing walls. Within each column the molecules interact with each other to form either left or right handed triple-helical arrangements with channels of 8.8 × 7.4 Å2 dimensions running along the axis of the triple helix. Adjacent strands of each triple helix are separated by a distance of 6.7 Å with the accompanying void space filled by interweaving of triple helices from an adjacent network. The helices of adjacent triple-helical network are connected by N–H⋯O hydrogen bonds and helices of different networks interact with each other by C–H⋯N hydrogen bonds.

Graphical abstract: A hydrogen bonded cocrystal with an unusual interweaving between the adjacent triple-helices

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Article information

DOI
https://doi.org/10.1039/C1CE05534H
Article type
Communication
Submitted
07 May 2011
Accepted
19 Aug 2011
First published
08 Sep 2011

CrystEngComm, 2011,13, 6315-6318

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A hydrogen bonded cocrystal with an unusual interweaving between the adjacent triple-helices

A. Delori and W. Jones, CrystEngComm, 2011, 13, 6315 DOI: 10.1039/C1CE05534H

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