Issue 26, 2011
From the journal:

Chemical Communications

Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling†

Philipp Heretsch,a   Anita Büttner,a   Lito Tzagkaroulaki,a   Stefan Zahn,b   Barbara Kirchner*b  and  Athanassios Giannis*a  

* Corresponding authors

a Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, D-04103 Leipzig, Germany
E-mail: giannis@uni-leipzig.de
Fax: +49-341-97-36599
Tel: +49 341 97 36581

b Wilhelm-Ostwald-Institut für Physikalische und Theoretische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Linnéstraße 2, D-04103 Leipzig, Germany
E-mail: bkirchner@uni-leipzig.de
Fax: +49 341 97 36399
Tel: +49 341 97 36500

Abstract

The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.

Graphical abstract: Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

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Article information

DOI
https://doi.org/10.1039/C1CC11782C
Article type
Communication
Submitted
29 Mar 2011
Accepted
22 Apr 2011
First published
17 May 2011

Chem. Commun., 2011,47, 7362-7364

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Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner and A. Giannis, Chem. Commun., 2011, 47, 7362 DOI: 10.1039/C1CC11782C

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