Issue 38, 2010
From the journal:

Physical Chemistry Chemical Physics

Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

Tanja Deckert-Gaudiga  and  Volker Deckert*ab  

* Corresponding authors

a Institute for Photonic Technology, Albert-Einstein. Str. 9, D-07745 Jena, Germany
E-mail: tanja.deckert-gaudig@ipht-jena.de
Tel: +49 3641 948322

b Universität Jena, Institut für Physikalische Chemie, Helmholtzstr. 4, D-07743 Jena, Germany
E-mail: volker.deckert@uni-jena.de
Fax: +49 3641 948302
Tel: +49 3641 48347

Abstract

This perspective presents and assesses the development and capabilities of tip-enhanced Raman scattering (TERS) since its discovery in 2000. So far, this technique has proven to be valuable for studies of a variety of inorganic, organic and biochemical specimens. Due to its ability to provide chemical and topographic characterization in a single experiment at a sub-100 nm resolution, TERS has gained importance in super-resolution structural analysis. In this contribution the focus is set on applications with relevance in the biology and medical fields. The potential and challenges of this near-field technique are discussed with respect to state-of-the-art microscopic and spectroscopic imaging methods. Furthermore, possible ways to surpass current boundaries and an outlook to future projects are presented.

Graphical abstract: Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

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Article information

DOI
https://doi.org/10.1039/C003316B
Article type
Perspective
Submitted
17 Feb 2010
Accepted
19 Jul 2010
First published
23 Aug 2010

Phys. Chem. Chem. Phys., 2010,12, 12040-12049

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Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

T. Deckert-Gaudig and V. Deckert, Phys. Chem. Chem. Phys., 2010, 12, 12040 DOI: 10.1039/C003316B

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