Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

Semin Lee; Alan Brown; William Ross Pitt; Alicia Perez Higueruelo; Sungsam Gong; George Richard Bickerton; Adrian Schreyer; Duangrudee Tanramluk; Alison Baylay; Tom Leon Blundell

doi:10.1039/B906402H

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics†

Semin Lee,‡^a Alan Brown,‡^a William Ross Pitt,‡^ab Alicia Perez Higueruelo,^a Sungsam Gong,^a George Richard Bickerton,^a Adrian Schreyer,^a Duangrudee Tanramluk,^a Alison Baylay^a and Tom Leon Blundell*^a

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* Corresponding authors

^a Department of Biochemistry, University of Cambridge, Old Addenbrookes site, 80 Tennis Court Road, Cambridge, UK
E-mail: tom@cryst.bioc.cam.ac.uk
Fax: +44 (0)1223 766082
Tel: +44 (0)1223 333628

^b UCB Celltech, 208 Bath Road, Slough, Berkshire, UK

Abstract

Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblastgrowth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.

This article is part of the themed collection: Computational and systems biology

Molecular BioSystems

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics†

Abstract

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