Issue 20, 2002

Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization

Abstract

From readily available allylamine, aldehyde and isocyanoacetamide, a three-component reaction followed by a Pummerer cyclization provided tetracyclic ring systems (6-7-5-6 and 6-6-5-6) in excellent overall yields.

Graphical abstract: Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization

Article information

Article type
Communication
Submitted
24 Jul 2002
Accepted
09 Sep 2002
First published
24 Sep 2002

Chem. Commun., 2002, 2448-2449

Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization

R. G. Montaño and J. Zhu, Chem. Commun., 2002, 2448 DOI: 10.1039/B207179G

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