Issue 44, 2023

Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Abstract

We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells.

Graphical abstract: Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Supplementary files

Article information

Article type
Communication
Submitted
10 Mar 2023
Accepted
07 May 2023
First published
12 May 2023

Chem. Commun., 2023,59, 6706-6709

Author version available

Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

M. Tsuji, H. Taira, T. Udagawa, T. Aoki, T. Hirayama and H. Nagasawa, Chem. Commun., 2023, 59, 6706 DOI: 10.1039/D3CC01192E

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