Issue 5, 2015
From the journal:

Soft Matter

Dynamic membrane patterning, signal localization and polarity in living cells

M. Zamparo,†ab   F. Chianale,†a   C. Tebaldi,b   M. Cosentino-Lagomarsino,c   M. Nicodemi*d  and  A. Gamba*ab  

* Corresponding authors

a Human Genetics Foundation – Torino, Italy
E-mail: andrea.gamba@polito.it

b DISAT, Politecnico di Torino, INFN and CNISM, Italy

c CNRS, Université Pierre and Marie Curie, Paris, France

d Dip. di Fisica, Università di Napoli, INFN and CNR-SPIN, Italy
E-mail: mario.nicodemi@na.infn.it

Abstract

We review the molecular and physical aspects of the dynamic localization of signaling molecules on the plasma membranes of living cells. At the nanoscale, clusters of receptors and signaling proteins play an essential role in the processing of extracellular signals. At the microscale, “soft” and highly dynamic signaling domains control the interaction of individual cells with their environment. At the multicellular scale, individual polarity patterns control the forces that shape multicellular aggregates and tissues.

Graphical abstract: Dynamic membrane patterning, signal localization and polarity in living cells

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Article information

DOI
https://doi.org/10.1039/C4SM02157F
Article type
Review Article
Submitted
26 Sep 2014
Accepted
08 Dec 2014
First published
08 Dec 2014

Soft Matter, 2015,11, 838-849

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Dynamic membrane patterning, signal localization and polarity in living cells

M. Zamparo, F. Chianale, C. Tebaldi, M. Cosentino-Lagomarsino, M. Nicodemi and A. Gamba, Soft Matter, 2015, 11, 838 DOI: 10.1039/C4SM02157F

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