Issue 30, 2013
From the journal:

RSC Advances

Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

Vaibhav P. Mehta*ab  and  Benudhar Punji*c  

* Corresponding authors

a C-5, Rushikesh Apartment, Opp. Viral Baug, Nr. Pratap Vilas Palace, Jamnagar–361 008, Gujarat, India

b School of Chemistry, The University of Manchester, Oxford Road, M13 9PL Manchester, U.K.
E-mail: vaibhav.mehta@manchester.ac.uk

c Organometallic Synthesis and Catalysis Group, Chemical Engineering Division, CSIR–National Chemical Laboratory (CSIR–NCL), Dr Homi Bhabha Road, Pune–411 008, Maharashtra, India
E-mail: b.punji@ncl.res.in
Fax: 91-20-2590 2621
Tel: +91-20-2590 2733

Abstract

The efficient generation of biaryl compounds and heterocycles via the advent of the transition-metal-free coupling reaction constitutes an important development in the last few years. Although early methods for the construction of such molecules involved transition metals, recent advances in the field have witnessed a myriad of elegant reports without the use of metal sources. The serendipitous discovery and observation of synthetic chemists have realized that there lies a great potential in exploiting the inherent reactivity of molecules in absence of transition metal. The key to the success of such coupling reactions is the use of a strong base, oxidant and a catalytic amount of N-donor ligands which contribute significantly. This review aims to highlight the recent progress in the field of transition-metal-free direct C–C and C–heteroatom bond forming reactions via the use of a strong base and (or) an oxidant.

Graphical abstract: Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

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Article information

DOI
https://doi.org/10.1039/C3RA40813B
Article type
Review Article
Submitted
19 Feb 2013
Accepted
05 Apr 2013
First published
08 Apr 2013

RSC Adv., 2013,3, 11957-11986

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Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

V. P. Mehta and B. Punji, RSC Adv., 2013, 3, 11957 DOI: 10.1039/C3RA40813B

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