Issue 80, 2013

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

Abstract

The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (log K = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter.

Graphical abstract: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2013
Accepted
05 Aug 2013
First published
07 Aug 2013

Chem. Commun., 2013,49, 9134-9136

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

X. Du, H. Li, X. Wang, Q. Liu, J. Ni and H. Sun, Chem. Commun., 2013, 49, 9134 DOI: 10.1039/C3CC45360J

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