Issue 8, 2010
From the journal:

Dalton Transactions

“Click” labeling strategy for M(CO)3 (M = Re, 99mTc) prostate cancer targeted Flutamide agents†

Adam L. Moore,a   Dejan-Krešimir Bučar,b   Leonard R. MacGillivrayb  and  Paul D. Benny*a  

* Corresponding authors

a Department of Chemistry, Washington State University, Pullman, WA, USA
E-mail: bennyp@wsu.edu
Fax: 509-335-8867
Tel: 509-335-3858

b Department of Chemistry, University of Iowa, Iowa City, IA, USA
E-mail: len-macgillivray@uiowa.edu
Fax: 319-335-1270
Tel: 319-335-3504

Abstract

Two distinct “click” chemistry labeling approaches were investigated with dipyridylamine alkyne derivatives and M(CO)3+ (M = Re, 99mTc). The triazole ring was found uncoordinated and was incorporated into the preparation of a crossover androgen receptor targeting inhibitor for prostate cancer.

Graphical abstract: “Click” labeling strategy for M(CO)3 (M = Re, 99mTc) prostate cancer targeted Flutamide agents

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Article information

DOI
https://doi.org/10.1039/B921413E
Article type
Communication
Submitted
14 Oct 2009
Accepted
15 Dec 2009
First published
06 Jan 2010

Dalton Trans., 2010,39, 1926-1928

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“Click” labeling strategy for M(CO)3 (M = Re, 99mTc) prostate cancer targeted Flutamide agents

A. L. Moore, D. Bučar, L. R. MacGillivray and P. D. Benny, Dalton Trans., 2010, 39, 1926 DOI: 10.1039/B921413E

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