Issue 38, 2009
From the journal:

Chemical Communications

Application of REDORNMR in natural product chemistry

Shigeru Matsuoka*a  and  Masayuki Inoue*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo, Japan
E-mail: inoue@mol.f.u-tokyo.ac.jp
Fax: +81-35841-1354
Tel: +81-35841-0568

Abstract

Many natural products have molecular targets that are non-crystalline and insoluble biological matrices, such as proteins embedded in lipid membrane, cell membranes, and cell walls. To understand the action mechanisms, it is essential to determine the binding structure with atomic-level resolution. For structural studies of biological solids, high resolution distance measurements using solid-state nuclear magnetic resonance (NMR) are indispensable techniques, of which rotational-echo double-resonance (REDOR) is one of the most widely used methods. This feature article introduces the basic concepts of REDORNMR and its application to the structural study of natural products in biological matrices.

Graphical abstract: Application of REDORNMR in natural product chemistry

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Article information

DOI
https://doi.org/10.1039/B910230B
Article type
Feature Article
Submitted
26 May 2009
Accepted
02 Jul 2009
First published
04 Aug 2009

Chem. Commun., 2009, 5664-5675

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Application of REDORNMR in natural product chemistry

S. Matsuoka and M. Inoue, Chem. Commun., 2009, 5664 DOI: 10.1039/B910230B

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