Issue 12, 2009
From the journal:

Molecular BioSystems

Stable G-quadruplexes are found outside nucleosome-bound regions†

Han Min Wonga  and  Julian Leon Huppert*a  

* Corresponding authors

a Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UK
E-mail: jlh29@cam.ac.uk

Abstract

Unusual DNA structures such as four-stranded G-quadruplexes have been found to form in vivo and to play regulatory roles. However, since DNA is normally present as chromatin, with the double helix wrapped around histoneproteins, it is unclear how a G-quadruplex could form in such a region. Here, we show that regulatory G-quadruplexes found upstream of transcription start sites are in fact located in a region depleted of nucleosomes, and that in general in both Caenorhabditis elegans and humans, stable G-quadruplexes are located outside nucleosome-bound regions, hence making it easier for them to form in vivo.

Graphical abstract: Stable G-quadruplexes are found outside nucleosome-bound regions

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Article information

DOI
https://doi.org/10.1039/B905848F
Article type
Paper
Submitted
24 Mar 2009
Accepted
15 Apr 2009
First published
14 May 2009

Mol. BioSyst., 2009,5, 1713-1719

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Stable G-quadruplexes are found outside nucleosome-bound regions

H. M. Wong and J. L. Huppert, Mol. BioSyst., 2009, 5, 1713 DOI: 10.1039/B905848F

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