Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

Steven J. Moss; Isabelle Carletti; Carlos Olano; Rose M. Sheridan; Michael Ward; Vidya Math; Mohammad Nur-E-Alam; Alfredo F. Braña; Ming Qiang Zhang; Peter F. Leadlay; Carmen Méndez; José A. Salas; Barrie Wilkinson

doi:10.1039/B602931K

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues†

Steven J. Moss,‡^a Isabelle Carletti,‡^a Carlos Olano,^b Rose M. Sheridan,^a Michael Ward,^a Vidya Math,^a Mohammad Nur-E-Alam,^a Alfredo F. Braña,^b Ming Qiang Zhang,^a Peter F. Leadlay,^c Carmen Méndez,^b José A. Salas^b and Barrie Wilkinson*^a

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^a Biotica, Chesterford Research Park, Little Chesterford, UK
E-mail: barrie.wilkinson@biotica.com
Fax: +44 (0)1799 532920
Tel: +44 (0)1799 532925

^b Departamento de Biologia Funciona e Instituto Universitario de Oncologia del Principado de Asturias (I.U.O.P.A.), Universidad de Oviedo, 33006 Oviedo, Spain

^c Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK

Abstract

We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.

Chemical Communications

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues†

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Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

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