Issue 61, 2015
From the journal:

RSC Advances

The molecular mechanism of conformational changes of the triplet prion fibrils for pH†

Hyunsung Choi,a   Hyun Joon Chang,a   Yongwoo Shin,b   Jae In Kim,a   Harold S. Park,c   Gwonchan Yoon*ac  and  Sungsoo Na*a  

* Corresponding authors

a Department of Mechanical Engineering Korea University, Seoul 136-701, Republic of Korea
E-mail: gyoon1@bu.edu, nass@korea.ac.kr

b Department of Mechanical Engineering and Division of Materials Science and Engineering, Boston University, Boston, MA, USA

c Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA

Abstract

The HET-s prion fibril, which is found in the filamentous fungus Podospora anserina, exhibits conformational changes due to variations in pH. Here, we explain the effects of changing pH on the conformational changes of fibrils through the fundamental eigenmodes of the fibrils, in particular the torsional and bending modes, using a parameter free elastic network model. In particular, the motion resulting from these fundamental eigenmodes is found to be very similar to the conformational changes stimulated by pH variations as shown in previous experimental results. Finally, we calculated the mechanical properties of the triplet prion fibrils to elucidate its variations in the infectious state.

Graphical abstract: The molecular mechanism of conformational changes of the triplet prion fibrils for pH

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Article information

DOI
https://doi.org/10.1039/C5RA08015K
Article type
Communication
Submitted
01 May 2015
Accepted
27 May 2015
First published
27 May 2015

RSC Adv., 2015,5, 49263-49269

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The molecular mechanism of conformational changes of the triplet prion fibrils for pH

H. Choi, H. J. Chang, Y. Shin, J. I. Kim, H. S. Park, G. Yoon and S. Na, RSC Adv., 2015, 5, 49263 DOI: 10.1039/C5RA08015K

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