Issue 32, 2015
From the journal:

Chemical Communications

Enzyme-catalysed deposition of ultrathin silver shells on gold nanorods: a universal and highly efficient signal amplification strategy for translating immunoassay into a litmus-type test†

Xinjian Yanga  and  Zhiqiang Gao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
E-mail: chmgaoz@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-3887

Abstract

On the basis of enzyme-catalysed reduction of silver ions and consequent deposition of ultrathin silver shells on gold nanorods, a highly efficient signal amplification method for immunoassay is developed. For a model analyte prostate-specific antigen, a 104-fold improvement over conventional enzyme-linked immunosorbent assay is accomplished by leveraging on the cumulative nature of the enzymatic reaction and the sensitive response of plasnomic gold nanorods to the deposition the silver shells.

Graphical abstract: Enzyme-catalysed deposition of ultrathin silver shells on gold nanorods: a universal and highly efficient signal amplification strategy for translating immunoassay into a litmus-type test

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Article information

DOI
https://doi.org/10.1039/C5CC01286D
Article type
Communication
Submitted
11 Feb 2015
Accepted
13 Mar 2015
First published
20 Mar 2015

Chem. Commun., 2015,51, 6928-6931

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Enzyme-catalysed deposition of ultrathin silver shells on gold nanorods: a universal and highly efficient signal amplification strategy for translating immunoassay into a litmus-type test

X. Yang and Z. Gao, Chem. Commun., 2015, 51, 6928 DOI: 10.1039/C5CC01286D

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