Issue 12, 2014

Late-stage [18F]fluorination: new solutions to old problems

Abstract

The last 2–3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.

Graphical abstract: Late-stage [18F]fluorination: new solutions to old problems

Article information

Article type
Perspective
Submitted
15 Jul 2014
Accepted
21 Aug 2014
First published
25 Aug 2014

Chem. Sci., 2014,5, 4545-4553

Author version available

Late-stage [18F]fluorination: new solutions to old problems

A. F. Brooks, J. J. Topczewski, N. Ichiishi, M. S. Sanford and P. J. H. Scott, Chem. Sci., 2014, 5, 4545 DOI: 10.1039/C4SC02099E

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