Gold amides as anticancer drugs: synthesis and activity studies

Sonya Newcombe; Mariusz Bobin; Amruta Shrikhande; Chris Gallop; Yannick Pace; Helen Yong; Rebecca Gates; Shuvashri Chaudhuri; Mark Roe; Eva Hoffmann; Eddy M. E. Viseux

doi:10.1039/C3OB27460H

Gold amides as anticancer drugs: synthesis and activity studies†

Sonya Newcombe,‡^b Mariusz Bobin,‡^ab Amruta Shrikhande,‡^b Chris Gallop,^a Yannick Pace,^ab Helen Yong,^b Rebecca Gates,^b Shuvashri Chaudhuri,^ab Mark Roe,^a Eva Hoffmann*^b and Eddy M. E. Viseux*^a

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* Corresponding authors

^a School of Life Sciences, Department of Chemistry, University of Sussex, Brighton, UK
E-mail: e.m.e.viseux@sussex.ac.uk
Tel: +44 (0) 1273 678621

^b MRC Genome Damage and Stability Centre, University of Sussex, Brighton, UK
E-mail: eh58@sussex.ac.uk
Tel: +44 (0) 1273 678121

Abstract

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

Organic & Biomolecular Chemistry

Gold amides as anticancer drugs: synthesis and activity studies†

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Gold amides as anticancer drugs: synthesis and activity studies

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