Issue 8, 2011
From the journal:

Organic & Biomolecular Chemistry

Novel biotinylated bile acidamphiphiles: Micellar aggregates formation and interaction with hepatocytes†

Luca Rizzi,a   Marta Braschi,a   Miriam Colombo,bc   Nadia Vaiana,a   Gianpaolo Tibolla,d   Giuseppe Danilo Norata,d   Alberico Luigi Catapano,d   Sergio Romeo*a  and  Davide Prosperi*bc  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Università degli Studi di Milano, Milano, Italy
E-mail: sergio.romeo@unimi.it
Fax: (+39)02503 19359
Tel: (+39)02503 19363

b Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, P.zza della Scienza 2, Milano, Italy
E-mail: davide.prosperi@unimib.it
Fax: (+39)026448 3565
Tel: (+39)02644 83302

c Centro di Microscopia Elettronica per le nanotecnologie applicate alla medicina (CMENA), Università di Milano, Via G.B. Grassi 74, Milano, Italy

d Dipartmento di Scienze Farmacologiche, Università degli Studi di Milano, Milano, Italy

Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.

Graphical abstract: Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

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Article information

DOI
https://doi.org/10.1039/C0OB00878H
Article type
Paper
Submitted
13 Oct 2010
Accepted
04 Feb 2011
First published
03 Mar 2011

Org. Biomol. Chem., 2011,9, 2899-2905

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Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

L. Rizzi, M. Braschi, M. Colombo, N. Vaiana, G. Tibolla, G. D. Norata, A. L. Catapano, S. Romeo and D. Prosperi, Org. Biomol. Chem., 2011, 9, 2899 DOI: 10.1039/C0OB00878H

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