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Genetic alterations of the MYH gene in gastric cancer

Oncogene volume 23, pages 6820–6822 (2004)Cite this article

Abstract

Increased oxygen free radicals produced in gastric mucosa by H. pylori induce DNA damage and lead to dyspalsia and gastric cancers. However, only a small percentage of individuals that carry H. pylori develop gastric cancer, indicating that other factors are involved. We have screened a set of 95 sporadic gastric cancers for mutations and allele loss of the DNA glycosylase MYH gene, which excises adenine misincorporated opposite unrepaired 8-oxoG. Two of 95 cancers had bi-allelic mutations of the MYH gene with somatic missense mutation of one allele and loss of the remaining allele. The mutations were missense mutations, P391S and Q400R, in exon 13 encoding NUDIX hydrolase domain of the gene. The patients were H. pylori-positive and the tumors were of advanced intestinal-type gastric cancer with lymph node metastasis. In addition, 4 (17.4%) of 23 informative cases showed allele loss at MYH locus. Therefore, our data suggest that somatic mutations of base excision repair gene MYH contribute to the development of a sub-set of sporadic gastric cancers.

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Acknowledgements

This work was supported by the Ministry of Health and Welfare of Korea (02-PJ1-PG10-20699-0004).

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea

    Chang Jae Kim, Yong Gu Cho, Su Young Kim, Suk Woo Nam, Sug Hyung Lee, Nam Jin Yoo, Jung Young Lee & Won Sang Park

  2. Department of Surgery, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea

    Cho Hyun Park

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  1. Chang Jae Kim
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Correspondence to Won Sang Park.

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Kim, C., Cho, Y., Park, C. et al. Genetic alterations of the MYH gene in gastric cancer. Oncogene 23, 6820–6822 (2004). https://doi.org/10.1038/sj.onc.1207574

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