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The human papillomavirus type 16 E6 oncogene induces premature mitotic chromosome segregation

Oncogene volume 21, pages 7507–7513 (2002)Cite this article

Abstract

Expression of the human papillomavirus type 16 E6 and E7 oncogenes initiates and maintains abnormal cell replication, by interacting with the p53 and retinoblastoma (Rb) gene products. Subsequent changes in host cell gene expression, as a consequence of genetic instability, can result in progression to invasive carcinoma. In addition to previously described effects of these viral oncogenes on centrosome synthesis, primarily associated with the expression of E7, the results described herein demonstrate that the E6 oncogene can induce premature chromosome segregation in human cells.

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Acknowledgements

We thank Teri Sundsvold for excellent technical assistance. The research is supported by a National Institutes of Health grant, CA 42792, to J McDougall.

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Authors and Affiliations

  1. Department of Pathology, University of Washington, 1959 Pacific Street, N.E., Seattle, 98195-7407, Washington, WA, USA

    Annemieke W Plug-Demaggio & James K McDougall

  2. Fred Hutchinson Cancer Research Center, Cancer Biology Program, 1100 Fairview Avenue N., Seattle, 98109-1024, Washington, WA, USA

    Annemieke W Plug-Demaggio & James K McDougall

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  1. Annemieke W Plug-Demaggio
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  2. James K McDougall
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Correspondence to James K McDougall.

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Plug-Demaggio, A., McDougall, J. The human papillomavirus type 16 E6 oncogene induces premature mitotic chromosome segregation. Oncogene 21, 7507–7513 (2002). https://doi.org/10.1038/sj.onc.1205903

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