Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Harrison BD, Adams JA, Briggs M, Brereton ML, Yin JA . Stimulation of autologous proliferative and cytotoxic T-cell responses by ‘leukemic dendritic cells’ derived from blast cells in acute myeloid leukemia. Blood 2001; 97: 2764–2771.

    Article  CAS  Google Scholar 

  2. Choudhury A, Gajewski JL, Liang JC, Popat U, Claxton DF, Kliche KO et al. Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1997; 89: 1133–1142.

    CAS  Google Scholar 

  3. Mohty M, Isnardon D, Blaise D, Mozziconacci MJ, Lafage-Pochitaloff M, Briere et al. Identification of precursors of leukemic dendritic cells differentiated from patients with acute myeloid leukemia. Leukemia 2002; 16: 2267–2274.

    Article  CAS  Google Scholar 

  4. Mohty M, Olive D, Gaugler B . Leukemic dendritic cells: potential for therapy and insights towards immune escape by leukemic blasts. Leukemia 2001; 15: 545–558.

    Google Scholar 

  5. Matthes-Martin S, Mann G, Peters C, Lion T, Fritsch G, Haas OA et al. Allogeneic bone marrow transplantation for juvenile myelomonocytic leukaemia: a single centre experience and review of the literature. Bone Marrow Transplant 2000; 26: 377–382.

    Article  CAS  Google Scholar 

  6. Worth A, Rao K, Webb D, Chessells J, Passmore J, Veys P . Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion. Blood 2003; 101: 1713–1714.

    Article  CAS  Google Scholar 

  7. Banchereau J, Steinman RM . Dendritic cells and the control of immunity. Nature 1998; 392: 245–252.

    Article  CAS  Google Scholar 

  8. Longoni D, D’Amico G, Gaipa G, Bernasconi S, Vulcano M, Onnis P et al. Commitment of juvenile myelo-monocytic (JMML) leukemic cells to spontaneously differentiate into dendritic cells. Hematol J 2002; 3: 302–310.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the patients who provided blood samples as well as Dr P Veys, Dr D Webb and Netty Hewitt for sample collection and advice. This work was supported by the Research into Childhood Cancer (RICC), Gibraltar, The Wellcome Trust, The Medical Research Council and Cancer Research UK. Research at the Institute of Child Health and Great Ormond Street Hospital for Children National Health Service trust benefits from Research and Development funding received from the NHS executive.

The views expressed in this publication are those of the authors and are not necessarily those of the NHS executive.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nabarro, S., Thrasher, A., Kempski, H. et al. Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia. Leukemia 17, 1910–1912 (2003). https://doi.org/10.1038/sj.leu.2403059

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403059

This article is cited by

Search

Quick links