Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Auditory Brainstem Response Detects Early Bilirubin Neurotoxicity at Low Indirect Bilirubin Values

Abstract

When sedation, prematurity or other disease processes mask symptoms in the clinically ill newborn, serum bilirubin concentration is monitored as the sole indicator of kernicterus risk. This case emphasizes the value of auditory brainstem responses for the management of indirect hyperbilirubinemia complicated by prematurity, hemolytic anemia, asphyxia, and direct hyperbilirubinemia.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Perlman M, Frank JW . Bilirubin beyond the blood – brain barrier. Pediatrics 1988;81:304–315.

    CAS  PubMed  Google Scholar 

  2. Agrawal VK, Shukla R, Misra PK, Kapoor RK, Malik GK . Brainstem auditory evoked response in newborns with hyperbilirubinemia. Indian Pediatr 1998;35:513–518.

    CAS  PubMed  Google Scholar 

  3. Gupta AK, Anand NK, Hans R . Evaluation of risk factors for hearing impairment in at risk neonates by brainstem evoked response auditometry (BERA). Indian J Pediatr 1991;58:849–855.

    Article  CAS  Google Scholar 

  4. Kuriyama M, Tomiwa K, Konishi Y, Mikawa H . Improvement of auditory brainstem response of hyperbilirubinemic infants after exchange transfusions. Pediatr Neurol 1986;2:127–132.

    Article  CAS  Google Scholar 

  5. Lee CY, Chen SJ, Tang RB . Reevaluation of recent criteria for blood exchange transfusion in term infants with hyperbilirubinemia. Acta Paediatr Tw 2002;43:86–90.

    Google Scholar 

  6. Nakamura H, Takada S, Shimabuku R, Matsuo M, Matsuo T, Negishi H . Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia. Pediatrics 1985;75:703–708.

    CAS  PubMed  Google Scholar 

  7. Nwaesei CG, Van Aerde J, Boyden M, Perlman M . Changes in auditory brainstem responses in hyperbilirubinemic infants before and after exchange transfusion. Pediatrics 1984;74:800–803.

    CAS  PubMed  Google Scholar 

  8. Wennberg RP, Ahlfors CE, Bickers R, McMurtry CA, Shetter JL . Abnormal brainstem auditory in newborn infant with hyperbilirubinemia: improvement with exchange transfusion. J Pediatr 1982;100:624.

    Article  CAS  Google Scholar 

  9. Chisin R, Perlman M, Sohmer H . Cochlear and brain stem responses in hearing loss following neonatal hyperbilirubinemia. Ann Otol Rhinol Laryngol 1979;88:352–357.

    Article  CAS  Google Scholar 

  10. Soares I, Collet L, Delorme C, Salle B, Morgon A . Are click-evoked BAEPs useful in case of neonate hyperbilirubinemia? Int J Pediatr Otorhinolaryngol 1989;17:231–237.

    Article  CAS  Google Scholar 

  11. Lenhardt ML, McActor R, Bryant B . Effects of neonatal hyperbilirubinemia on the brainstem electric response. J Pediatr 1984;104:281–284.

    Article  CAS  Google Scholar 

  12. Vohr BR, Karp D, O’Dea C, et al. Behavioral changes correlated with brain-stem auditory evoked responses in term infants with mderate hyperbilirubinemia. J Pediatr 1990;117:288–291.

    Article  CAS  Google Scholar 

  13. DeVries LS, Lary S, Whitelaw AG, Dubowitz LMS . Relationship of serum bilirubin levels and hearing impairment in newborn infants. Early Hum Dev 1987;15:269–277.

    Article  CAS  Google Scholar 

  14. Deliac P, Demarquez JL, Barberot JP, Sandler B, Paty J . Brainstem auditory evoked potentials in icteric fullterm newborns: alterations after exchange transfusion. Neuropediatrics 1990;21:115–118.

    Article  CAS  Google Scholar 

  15. Bhandari V, Narang A, Mann SBS, Raghunathan M, Bhakoo ON . Brain stem electric response audiometry in neonates with hyperbilirubinemia. Indian J Pediatr 1993;60:409–413.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smith, C., Barnes, G., Jacobson, C. et al. Auditory Brainstem Response Detects Early Bilirubin Neurotoxicity at Low Indirect Bilirubin Values. J Perinatol 24, 730–732 (2004). https://doi.org/10.1038/sj.jp.7211164

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211164

This article is cited by

Search

Quick links