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Elevated high-sensitive C-reactive protein, large arterial stiffness and atherosclerosis: a relationship between inflammation and hypertension?

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References

  1. Murray CJ, Lopez AD . Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997; 349: 1436–1442.

    Article  CAS  Google Scholar 

  2. Szmitko PE et al. New markers of inflammation and endothelial cell activation: Part I. Circulation 2003; 108: 1917–1923.

    Article  Google Scholar 

  3. Szmitko PE et al. Biomarkers of vascular disease linking inflammation to endothelial activation: Part II. Circulation 2003; 108: 2041–2048.

    Article  Google Scholar 

  4. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–2497.

  5. Ridker PM . High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001; 103: 1813–1818.

    Article  CAS  Google Scholar 

  6. Du Clos TW . Function of C-reactive protein. Ann Med 2000; 32: 274–278.

    Article  CAS  Google Scholar 

  7. Danesh J et al. Low grade inflammation and coronary heart. BMJ 2000; 321: 199–204.

    Article  CAS  Google Scholar 

  8. Dernellis J, Panaretou M . Relationship between C-reactive protein concentrations during glucocorticid treatment and recurrent atrial fibrillation. Eur Heart J 2004; 25: 1100–1107.

    Article  CAS  Google Scholar 

  9. Willerson JT, Ridker PM . Inflammation as a cardiovascular risk factor. Circulation 2004; 109(21 Suppl 1): II2–II10.

    PubMed  Google Scholar 

  10. Liuzzo G et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. disease: prospective study and updated meta-analyses. N Engl J Med 1994; 331: 417–424.

    Article  CAS  Google Scholar 

  11. Ridker PM et al. Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1999; 100: 230–235.

    Article  CAS  Google Scholar 

  12. Di Napoli M, Papa F . Angiotensin-converting enzyme inhibitor use is associated with reduced plasma concentration of C-reactive protein in patients with first-ever ischemic stroke. Stroke 2003; 34: 2922–2929.

    Article  CAS  Google Scholar 

  13. Torzewski J et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol 1998; 18: 1386–1392.

    Article  CAS  Google Scholar 

  14. Van Popele NM et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454–460.

    Article  CAS  Google Scholar 

  15. Herrington DM et al. Relationship between arterial stiffness and subclinical aortic atherosclerosis. Circulation 2004; 110: 432–437.

    Article  Google Scholar 

  16. Oliver JJ, Webb DJ . Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003; 23: 554–566.

    Article  CAS  Google Scholar 

  17. Duprez DA et al. Relationship between C-reactive protein and arterial stiffness in asymptomatic population. J Hum Hypertens [E-pub ahead of print, 19 May 2005; doi:10.1038/sj.jhh.1001860].

  18. Yasmin MCM et al. C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol 2004; 24: 969–974.

    Article  CAS  Google Scholar 

  19. Mattace-Raso FU et al. C-reactive protein and arterial stiffness in older adults: the Rotterdam Study. Atherosclerosis 2004; 176: 111–116.

    Article  CAS  Google Scholar 

  20. Hommels MJ . C-reactive protein, atherosclerosis, and kidney function in hypertensive patients. J Hum Hypertens [E-pub ahead of print, 21 April 2005; doi:10.1038/sj.jhh.1001878].

  21. Bautista LE . Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence. J Hum Hypertens 2003; 17(4): 223–230.

    Article  CAS  Google Scholar 

  22. Schram MT et al. Aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisinopril as initial choice in hypertensive type II diabetic individuals: effects on albumin excretion, endothelial function and inflammation in a double-blind, randomized clinical trial. J Hum Hypertens [E-pub ahead of print, 13 January 2005; doi:10.1038/sj.jhh.1001812].

  23. King DE et al. Elevation of C-reactive protein in people with prehypertension. J Clin Hypertens 2004; 6: 562–568.

    Article  CAS  Google Scholar 

  24. Bautista LE, Vera LM, Arenas IA, Gamarra G . Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension. J Hum Hypertens 2005; 19: 149–154.

    Article  CAS  Google Scholar 

  25. Bautista LE et al. C-reactive protein an independent risk factor for essential hypertension? J Hypertens 2001; 19: 857–861.

    Article  CAS  Google Scholar 

  26. Bautista LE, Atwood JE, O'Malley PG, Taylor AJ . Association between C-reactive protein and hypertension in healthy middle-aged men and women. Coronary Artery Dis 2004; 15: 331–336.

    Article  Google Scholar 

  27. Sung KC et al. High sensitivity C-reactive protein as an independent risk factor for essential hypertension. Am J Hypertens 2003; 16: 429–433.

    Article  CAS  Google Scholar 

  28. Li X et al. Gender-specific association between pulse pressure and C-reactive protein in a Chinese population. J Hum Hypertens 2005 Jan 27 [Epub ahead of print].

  29. He FJ, MacGregor GA . Cost of poor pressure control in the UK: 62000 unnecessary deaths per year. J Hum Hypertens 2003; 17: 455–457.

    Article  CAS  Google Scholar 

  30. Willaims B et al. British Hypertension Society. Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society 2004-BHS IV. J Hum Hypertens 2004; 18(3): 139–185.

    Article  Google Scholar 

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Boos, C., Lip, G. Elevated high-sensitive C-reactive protein, large arterial stiffness and atherosclerosis: a relationship between inflammation and hypertension?. J Hum Hypertens 19, 511–513 (2005). https://doi.org/10.1038/sj.jhh.1001858

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