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Role of endothelin in stress-induced hypertension

Journal of Human Hypertension volume 16, pages S29–S33 (2002)Cite this article

Abstract

In this study we investigated the role of endogenous endothelin in the cardiovascular response to acute stress, ie mild footshocks in conscious rats. Footshock-stress significantly increased mean arterial pressure and heart rate (P < 0.05). Peripheral or intracerebroventricular (IVT) administration of BQ 788, a selective antagonist of ETB receptor, did not alter pressor response to footshocks. Intraperitoneal injections of BQ 123 (1 mg/kg), a selective antagonist of the ETA-receptor, had a tendency to decrease, while BQ 123 (203 ng/5 μl) IVT administration significantly reduced the pressor response to footshocks (−12 mm Hg, P < 0.001). Neither ETA nor ETB antagonists, when injected centrally or peripherally, altered basal blood pressure or heart rate. Our results may indicate a role of brain endothelin in the sympathetic mediated cardiovascular response to stress, via stimulation of ETA recertor.

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References

  1. Yanagisawa M et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells Nature 1988 332: 411–415

    Article  CAS  PubMed  Google Scholar 

  2. Mosqueda-García R et al. Endothelin as a neuropeptide: cardiovascular effects in the brainstem of normotensive rats Circ Res 1993 72: 20–35

    Article  PubMed  Google Scholar 

  3. Lee ME, De la Monte SM, Ng SC, Bloch KD, Quertermous T . Expression of the potent vasoconstrictor endothelin in the human central nervous system J Clin Invest 1990 86: 141–147

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. McCumber MW, Ross CA, Snyder SH . Endothelin in brain: receptors mitogenesis, and biosynthesis in glial cells Proc Nat Acad Sci USA 1990 87: 2359–2363

    Article  Google Scholar 

  5. Koseki Ch et al. Autoradiographic distribution of rat tissues binding sites for endothelin: a neuropeptide Am J Physiol 1989 256: R858–R866

    Article  CAS  PubMed  Google Scholar 

  6. Gulati A, Rebello S . Characteristics of endothelin receptors in the central nervous system of spontaneously hypertensive rats Neuropharmacology 1992 31: 243–250

    Article  CAS  PubMed  Google Scholar 

  7. Hori S et al. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors Endocrinology 1992 130: 1885–1895

    CAS  PubMed  Google Scholar 

  8. Warner TD et al. Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA Br J Pharmacol 1992 106: 948–952

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kuwaki T et al. Role of endothelin in central cardiorespiratory control: modern and classical approaches News Physiol Sci 1995 10: 228–233

    CAS  Google Scholar 

  10. Kuwaki T et al. Physiological role of brain endothelin in the central autonomic control: from neuron to Knockout mouse Prog Neurobiol 1997 51: 545–579

    Article  CAS  PubMed  Google Scholar 

  11. Kawano Y et al. The cardiovascular effect of intracerebroventricular andothelin in rats J Hypertens Suppl 1989 7: S22–S23

    Article  CAS  PubMed  Google Scholar 

  12. Nishimura M et al. Chronic intracerebroventricular infusions of endothelin elevate arterial pressure in rats J Hypertens 1991 9: 71–76

    Article  CAS  PubMed  Google Scholar 

  13. Hashim MA, Tadepalli AS . Hemodynamic responses evoked by endothelin from central cardiovascular neural substrates Am J Physiol 1992 262: H1–H9

    CAS  PubMed  Google Scholar 

  14. Wall KM, Nasr M, Ferguson AV . Actions of endothelin at the subfornical organ Brain Res 1992 570: 180–187

    Article  CAS  PubMed  Google Scholar 

  15. Fisher LA . Stress and cardiovascular physiology in animals In: Brown MR, Koob G, River K (eds) Stress: Neurobiology and Neuroendocrinology Dekker: New York 1990 pp 463–474

    Google Scholar 

  16. Severs SW, Summy-Long J, Taylor JS, Cannor JD . A central effect of angiotensin: release of pituitary pressor material J Pharmacol Exp Ther 1970 174: 27–34

    CAS  PubMed  Google Scholar 

  17. Israel A, Cierco M, Sosa B . Role of AT2 receptors in the vasodepressor response to footshocks in losartan pretreated rats. Involvement of kinins, nitric oxide and prostaglandins Eur J Pharmacol 2000 394: 103–108

    Article  CAS  PubMed  Google Scholar 

  18. Yamamoto T et al. Central effects of endothelin-1 on vasopressin and atrial natriuretic peptide release and cardiovascular and renal function in conscious rats J Cardiovasc Pharmacol 17, Suppl 1991 7: S316–S318

    Article  Google Scholar 

  19. Nakamura K et al. Central effects of endothelin and its antagonists on sympathetic and cardiovascular regulation in SHR-SP J Cardiovasc Pharmacol 1999 33: 876–882

    Article  CAS  PubMed  Google Scholar 

  20. Ouchi T et al. Central effect of endothelin on blood pressure in conscious rats Am J Physiol (Heart Circ Physiol 25) 1989 256: H1747–H1751

    Article  CAS  Google Scholar 

  21. Rossi NF, O'Leary DS, Chen H . Mechanisms of centrally administered ET-1-induced increases in systemic arterial pressure and AVP secretion Am J Physiol (Endocrinnol Metab 35) 1997 272: E126–E132

    Article  CAS  Google Scholar 

  22. Kurokawa K, Yamada H, Ochi J . Topographical distribution of neurons containing endothelin type a receptor in the rat brain J Comp Neurol 1997 389: 348–360

    Article  CAS  PubMed  Google Scholar 

  23. Mosqueda-García R, Yates K, O'Leary J, Inagami T . Cardiovascular and respiratory effect of endothelin in the ventrolateral medulla of normotensive rat Hypertension 1995 26: 263–271

    Article  PubMed  Google Scholar 

  24. Wiklund NP, Öhlén A, Cederqvist B . Inhibition of adrenergic neuroeffector transmission by endothelin in the guinea pig femoral artery Acta Physiol Scand 1988 134: 311–312

    Article  CAS  PubMed  Google Scholar 

  25. Wiklund NP, Öhlén A, Cederqvist B . Adrenergic neuromodulation by endothelin in guinea pig pulmonary artery Neurosci Lett 1989 101: 269–273

    Article  CAS  PubMed  Google Scholar 

  26. Suzuki Y et al. Effects of endothelin-1 on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs J Cardiovasc Pharmacol 1992 19: 905–910

    Article  CAS  PubMed  Google Scholar 

  27. Tabuchi Y et al. Effects of endothelin on neureffector junction in mesenteric arteries of hypertensive rats Hypertension 1990 15: 739–743

    Article  CAS  PubMed  Google Scholar 

  28. Wong-Dusting HK, Reid JJ, Rand MJ . Paradoxical effects of endothelin on cardiovascular noradrenergic neurotransmission Clin Exp Pharmacol Physiol 1989 16: 229–233

    Article  CAS  PubMed  Google Scholar 

  29. Bucher B, Paya D, Stoclet JC . Modulation of [3H]noradrenaline release by endothelin-1 in the rat tail artery Neurochem Int 1991 18: 455–459

    Article  CAS  PubMed  Google Scholar 

  30. Takeuchi A, Kimura T, Satoh S . Enhancement by endothelin-1 of the release of catecholamines from the canine adrenal gland in response to splancnic nerve stimulation Clin Exp Pharmacol Phys 1992 19: 663–666

    Article  CAS  Google Scholar 

  31. Mutafova-Yambolieva VN, Westfall DP . Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic co-transmission in the rat isolated tail artery Br J Pharmacol 1998 123: 136–142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by CDCH grant GP-06–10–4343–99 and IIF-05–96, Universidad Central de Venezuela.

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  1. Laboratory of Neuropeptides. School of Pharmacy. Universidad Central de Venezuela, Caracas, Venezuela

    M R Garrido & A Israel

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  1. M R Garrido
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  2. A Israel
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Correspondence to A Israel.

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Garrido, M., Israel, A. Role of endothelin in stress-induced hypertension. J Hum Hypertens 16 (Suppl 1), S29–S33 (2002). https://doi.org/10.1038/sj.jhh.1001338

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