Clinical Study
Eye (2005) 19, 258–263. doi:10.1038/sj.eye.6701488 Published online 23 July 2004
Ocular motility findings in chronic progressive external ophthalmoplegia
C Richardson1, T Smith1, A Schaefer2, D Turnbull2 and P Griffiths1
- 1Department of Ophthalmology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon, Tyne
- 2Department of Neurology, The University of Newcastle upon, Tyne
Correspondence: PG Griffiths, Department of Ophthalmology, Claremont Wing Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK. Tel: +44 191 2825447; Fax: +44 191 2275246; E-mail: p.g.griffiths@ncl.ac.uk
Received 6 August 2003; Accepted 12 November 2003; Published online 23 July 2004.
Abstract
Aims
To characterise the ocular motility features of chronic progressive external ophthalmoplegia by quantitative and semiquantitative means.
To assess the prevalence of diplopia and the binocular adaptations to nonaligned visual axes.
Method
We studied 25 patients with chronic progressive external ophthalmoplegia. In each case muscle biopsies were consistent with mitochondrial myopathy. All patients underwent cover test in the primary position, assessment of binocular status, and measurement of uniocular fields of fixation using the Goldmann perimeter.
Results
A total of 23 (92%) patients had an exo-deviation, with six (26%) of those having an associated vertical deviation: 12 patients were binocular. Of the 13 patients with a manifest deviation seven had diplopia and six had suppression. Of all paired extra-ocular muscles (EOM), 68% had symmetry of movement within 5° of each other.
Conclusion
Almost all patients had an exo-deviation. Diplopia was more common than expected. The majority of patients had symmetry of EOM limitation.
Keywords:
ophthalmoplegia, mitochondrial myopathy
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