Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Adoptive transfer of vitiligo after allogeneic peripheral blood stem cell transplant

Bone Marrow Transplantation volume 36, pages 745–746 (2005)Cite this article

Vitiligo is the most common disorder of pigmentation occurring with a frequency of 0.1–2.0% in various populations. It is an organ-specific autoimmune disease of the skin. The cutaneous depigmentation is usually patchy with a tendency to affect symmetrical areas of the skin at corresponding anatomical sites on each side of the body. The disease has been noted in increased frequency in patients and their relatives affected by other autoimmune endocrinopathies.1

We report the case of a 52-year-old female who was diagnosed with acute myelogenous leukemia (FAB: M1). She underwent standard induction chemotherapy with idarubicin and cytarabine and consolidation with high-dose cytarabine, and achieved complete remission. The patient's disease relapsed one and a half years later. She received reinduction and consolidation chemotherapy, followed by high-dose chemotherapy with busulfan and cytoxan and an HLA-identical allogeneic stem cell transplant. Both donor and recipient were seropositive for cytomegalovirus (CMV).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Alkhateeb A, Fain PR, Thody A et al. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res 2003; 16: 208–214.

    Article  Google Scholar 

  2. Naughton GK, Eisinger M, Bystryn JC . Antibodies to normal human melanocytes in vitiligo. J Exp Med 1983; 158: 246–251.

    Article  CAS  Google Scholar 

  3. Hertz KC, Gazze LA, Kirkpatrick CH, Katz SI . Autoimmune vitiligo: detection of antibodies to melanin-producing cells. N Engl J Med 1977; 297: 634–637.

    Article  CAS  Google Scholar 

  4. Norris DA, Kissinger RM, Naughton GM, Bystryn JC . Evidence for immunologic mechanisms in human vitiligo: patients’ sera induce damage to human melanocytes in vitro by complement-mediated damage and antibody-dependent cellular cytotoxicity. J Inves Dermatol 1988; 90: 783–789.

    Article  CAS  Google Scholar 

  5. Song Yao-Hua, Connor Ellen, Li Yangxin et al. The role of tyrosinase in autoimmune vitiligo. Lancet 1994; 344: 1049–1052.

    Article  CAS  Google Scholar 

  6. Wankowicz-Kalinsha A, van den Wijngaard RM, Tigges BJ et al. Immunopolarization of CD4 (+) and CD8 (+) T cells to Type-1-Like is associated with melanocyte loss in human vitiligo. Lab Invest 2003; 83: 683–695.

    Article  Google Scholar 

  7. Goulmy E, Schipper R, Pool J et al. Mismatches of minor histocompatibiligy antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 1996; 334: 281–285.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Pathology, West Virginia University, Morgantown, WV, USA

    A Campbell-Fontaine, J E Coad, R Kovach & S G Ericson

Authors
  1. A Campbell-Fontaine
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J E Coad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Kovach
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S G Ericson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Campbell-Fontaine, A., Coad, J., Kovach, R. et al. Adoptive transfer of vitiligo after allogeneic peripheral blood stem cell transplant. Bone Marrow Transplant 36, 745–746 (2005). https://doi.org/10.1038/sj.bmt.1705137

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705137

This article is cited by

Search

Advanced search

Quick links