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Cytokines

Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization

Bone Marrow Transplantation volume 31, pages 651–654 (2003)Cite this article

Summary:

In this report, we examined plasma stromal cell-derived factor-1 levels in normal healthy donors for allogeneic peripheral blood stem cell transplantation (PBSCT) and in patients for autologous PBSCT using an enzyme-linked immunosorbent assay. The average level of plasma stromal cell-derived factor-1 was 2197 pg/ml before granulocyte colony-stimulating factor administration and 1899 pg/ml on day 4, demonstrating a significant decrease in the peripheral blood of healthy donors (P=0.0003). In patients for autologous PBSCT, a significant decrease of plasma stromal cell-derived factor-1 in the peripheral blood was also observed (P=0.0464). However, the physiologic gradient of stromal cell-derived factor-1 between peripheral blood and bone marrow was never inverted in normal healthy donors or in autologous PBSCT patients. Our results suggest that stromal cell-derived factor-1 may not be involved in the granulocyte colony-stimulating factor-induced release of CD34+ cells to the peripheral blood. Further studies of a possible additive effect of granulocyte colony-stimulating factor and stromal cell-derived factor-1 are warranted.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikatacho, Okayama, 700-8558, Japan

    T Kozuka, F Ishimaru, K Fujii, K Masuda, K Kaneda, T Imai, N Fujii, K Shinagawa, K Ikeda, K Niiya, M Harada & M Tanimoto

  2. Central Clinical Laboratory, Okayama University Medical School, 2-5-1 Shikatacho, Okayama, 700-8558, Japan

    H Ishikura, S Hongo & T Watanabe

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  1. T Kozuka
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  2. F Ishimaru
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  6. T Imai
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  7. N Fujii
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  10. T Watanabe
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  11. K Shinagawa
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  14. M Harada
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Kozuka, T., Ishimaru, F., Fujii, K. et al. Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Bone Marrow Transplant 31, 651–654 (2003). https://doi.org/10.1038/sj.bmt.1703901

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  • DOI: https://doi.org/10.1038/sj.bmt.1703901

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