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Post Transplant Complications

N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation

Bone Marrow Transplantation volume 25, pages 993–996 (2000)Cite this article

Abstract

Three patients developed veno-occlusive disease of the liver (VOD) after allogeneic stem cell transplantation. On the day after diagnosis, N-acetylcysteine (NAC) was given, initially in loading doses and thereafter 50–150 mg/kg/day for 12 to 31 days. The maximum bilirubin levels were 137, 58 and 138 mmol/l in the three patients, respectively. After the introduction of NAC, bilirubin, aspertate aminotransferase, sIL-2 receptor and IL-8 decreased. All three patients achieved normal bilirubin levels and prothrombin times. To conclude, NAC may be useful for treatment of VOD. Bone Marrow Transplantation (2000) 25, 993–996.

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Acknowledgements

We thank the staff at the Centre for Allogeneic Stem cell Transplantation for expert patient care. We thank Inger Hammarberg for excellent typing of the manuscript. We thank Zoe and Francis Walsh for scrutinizing the English language. This study was supported by grants from the Swedish Cancer Society (0070-B97-11XBC), the Children’s Cancer Foundation (1997/073), the Swedish Medical Research Council (K98-06X-05971-18B), the FRF Foundation, the Tobias Foundation and the Ellen Bachrach Foundation.

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Authors and Affiliations

  1. Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    O Ringdén, M Remberger, P Hentschke, J Mattsson, S Klaesson & J Aschan

  2. Department of Clinical Immunology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    O Ringdén, M Remberger, P Hentschke & J Mattsson

  3. Department of Haematology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    S Lehmann & J Aschan

  4. Department of Paediatrics, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    S Klaesson

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  1. O Ringdén
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Ringdén, O., Remberger, M., Lehmann, S. et al. N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation. Bone Marrow Transplant 25, 993–996 (2000). https://doi.org/10.1038/sj.bmt.1702387

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