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British Journal of Cancer (2006) 95, 374-377.
doi:10.1038/sj.bjc.6603281
Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma
B A C van Dijk1,6, L J Schouten1, E Oosterwijk2, C A Hulsbergen-van de Kaa3, L A L M Kiemeney2,4, R A Goldbohm5, J A Schalken2 and P A van den Brandt1
1Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands
2Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
3Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
4Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
5Department of Food and Chemical Risk Analysis, TNO Nutrition and Food Research, PO Box 360, Zeist 3700 AJ, The Netherlands
Correspondence to: Dr LJ Schouten, E-mail: LJ.Schouten@epid.unimaas.nl
6Current address: Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands.
Received 24 April 2006; revised 19 June 2006; accepted 23 June 2006
We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.
Keywords: renal cell carcinoma; cigarette smoking; von Hippel-Lindau gene mutations; The Netherlands; cohort study
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
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