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CARDIOIMMUNOLOGY

Fibroblasts tune myocardial inflammation and remodeling

Nature Cardiovascular Research volume 1, pages 694–695 (2022)Cite this article

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The replacement of damaged cardiomyocytes by extracellular matrix-producing fibroblasts underpins adverse remodeling in the failing heart. New research finds that MHC class II-dependent fibroblast–CD4+ T cell interactions in the myocardium lead to fibroblast activation and exacerbate fibrotic remodeling of the myocardium.

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Fig. 1: Local antigen presentation by cardiac fibroblasts affects cardiac function.

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Acknowledgements

We thank N. Pikor for critical reading of the manuscript.

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Authors and Affiliations

  1. Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland

    Christian Perez-Shibayama, Cristina Gil-Cruz & Burkhard Ludewig

  2. Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland

    Burkhard Ludewig

Authors
  1. Christian Perez-Shibayama
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  2. Cristina Gil-Cruz
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  3. Burkhard Ludewig
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Corresponding author

Correspondence to Burkhard Ludewig.

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Competing interests

C.G.C., C.P.S. and B.L. are co-founders and shareholders of Stromal Therapeutics.

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Perez-Shibayama, C., Gil-Cruz, C. & Ludewig, B. Fibroblasts tune myocardial inflammation and remodeling. Nat Cardiovasc Res 1, 694–695 (2022). https://doi.org/10.1038/s44161-022-00119-4

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