Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biosensor development

A chemical solution for FRET(ful) pairs

Nature Chemical Biology volume 19, pages 1048–1049 (2023)Cite this article

Subjects

The development of biosensors has been slowed by the optimization required for each new iteration. Now, the ChemoX platform facilitates the expansion of sensor design, resulting in unique Förster resonance energy transfer pairings with versatile applications and optimized readouts.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Comparison of a conventional approach and the ChemoX platform.

References

  1. Greenwald, E. C., Mehta, S. & Zhang, J. Chem. Rev. 118, 11707–11794 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Algar, W. R., Hildebrandt, N., Vogel, S. S. & Medintz, I. L. Nat. Methods 16, 815–829 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. Piljić, A., de Diego, I., Wilmanns, M. & Schultz, C. ACS Chem. Biol. 6, 685–691 (2011).

    Article  PubMed  Google Scholar 

  4. Chen, L. et al. ACS Sens 8, 1518–1528 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Cambronne, X. A. & Kraus, W. L. Trends Biochem. Sci. 45, 858–873 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Frei, M. S. et al. Nat. Methods 19, 65–70 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Hellweg, L. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01350-1 (2023).

    Article  PubMed  Google Scholar 

  8. Los, G. V. et al. ACS Chem. Biol. 3, 373–382 (2008).

    Article  CAS  PubMed  Google Scholar 

  9. Grimm, J. B. & Lavis, L. D. Nat. Methods 19, 149–158 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. Murakoshi, H., Shibata, A. C. E., Nakahata, Y. & Nabekura, J. Sci. Rep. 5, 15334 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA

    Scott N. Lyons & Xiaolu A. Cambronne

Authors
  1. Scott N. Lyons
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaolu A. Cambronne
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaolu A. Cambronne.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lyons, S.N., Cambronne, X.A. A chemical solution for FRET(ful) pairs. Nat Chem Biol 19, 1048–1049 (2023). https://doi.org/10.1038/s41589-023-01403-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-023-01403-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing