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GPCRs

Designer adhesion GPCR tells its signaling story

Nature Chemical Biology volume 16, pages 1280–1281 (2020)Cite this article

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The ADGRL3 receptor, a member of the adhesion G-protein-coupled receptor family, is implicated in many neurological diseases. Using a novel technique involving controlled proteolysis of the receptor’s extracellular domain, this study demonstrated that ADGRL3 signals via G12/13 G proteins.

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Fig. 1: Engineered turn on switch for adhesion GPCRs reveals ADGRL3 signaling pathway.

References

  1. Mathiasen, S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0617-7 (2020).

  2. Paavola, K. J. & Hall, R. A. Mol. Pharmacol. 82, 777–783 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Vizurraga, A., Adhikari, R., Yeung, J., Yu, M. & Tall, G.G. J. Biol. Chem. https://doi.org/10.1074/jbc.REV120.007423 (2020).

  4. Moreno-Salinas, A. L. et al. Front. Neurosci. https://doi.org/10.3389/fnins.2019.00700 (2019).

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Authors and Affiliations

  1. Department of Pharmacology, Vanderbilt University, Nashville, TN, USA

    Eugenia V. Gurevich & Vsevolod V. Gurevich

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  1. Eugenia V. Gurevich
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  2. Vsevolod V. Gurevich
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Correspondence to Eugenia V. Gurevich.

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The authors declare no competing interests.

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Gurevich, E.V., Gurevich, V.V. Designer adhesion GPCR tells its signaling story. Nat Chem Biol 16, 1280–1281 (2020). https://doi.org/10.1038/s41589-020-00673-7

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