In this issue of Nature Genetics, Lara-Astiaso et al. systematically characterized the functional roles of several chromatin factors in hematopoiesis by combining functional CRISPR screens with single-cell transcriptomics and chromatin accessibility profiling, revealing lineage biases and relationships with important transcription factors.
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References
Eaves, C. J. Blood. 125, 2605–2613 (2015).
Orkin, S. H. & Zon, L. I. Cell 132, 631–644 (2008).
Velten, L. et al. Nat. Cell Biol. 19, 271–281 (2017).
Wang, Z. et al. Signal Transduct. Target. Ther. 6, 24 (2021).
Rodrigues, C. P., Shvedunova, M. & Akhtar, A. Trends Genet. 37, 125–142 (2021).
Lara-Astiaso, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01471-2 (2023).
Dixit, A. et al. Cell 167, 1853–1866 (2016).
Moignard, V. et al. Nat. Cell Biol. 15, 363–372 (2013).
Novershtern, N. et al. Cell 144, 296–309 (2011).
You, J. S. & Jones, P. A. Cancer Cell 22, 9–20 (2012).
Shen, H. & Laird, P. W. Cell 153, 38–55 (2013).
Morin, R. D. et al. Nature 476, 298–303 (2011).
Abdel-Wahab, O. & Levine, R. L. Blood 121, 3563–3572 (2013).
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Solé-Boldo, L., Haas, S. Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis. Nat Genet 55, 1430–1431 (2023). https://doi.org/10.1038/s41588-023-01478-9
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DOI: https://doi.org/10.1038/s41588-023-01478-9