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LUNG CANCER

Frontline immunotherapy for NSCLC — the tale of the tail

Nature Reviews Clinical Oncology volume 17, pages 73–74 (2020)Cite this article

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The CHECKMATE-227 trial of nivolumab and ipilimumab presents a potential new frontline chemotherapy-sparing treatment option for patients with PD-L1-positive non-small-cell lung cancer and perhaps, in the future, also for those with PD-L1-negative disease. Indeed, the true predictive value of PD-L1 as well as tumour mutational burden remains to be determined, as neither biomarker segregates clearly with responsiveness.

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Fig. 1: Proposed first-line treatment algorithm for advanced-stage non-small-cell lung cancer without targetable driver mutations.

References

  1. Reck, M. et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N. Engl. J. Med. 346, 1823–1833 (2016).

    Article  Google Scholar 

  2. Mok, T. S. et al. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomized, open-label, controlled, phase 3 trial. Lancet. 393, 1819–1830 (2019).

    Article  CAS  Google Scholar 

  3. Spiegel, D. R. et al. LBA78 — IMpower110: Interim overall survival (OS) analysis of a phase III study of atezolizumab (atezo versus platinum-based chemotherapy (chemo) as first-line (1 L) treatment (tx) in PD-L1-selected NSCLC. Ann. Oncol. 30 (suppl. 5), v851–v934 (2019).

    Google Scholar 

  4. Reck, M. et al. OA14.01 KEYNOTE-024 3-year survival update: pembrolizumab versus platinum-based chemotherapy for advanced non-small-cell lung cancer. J. Thorac. Oncol. 14 (Suppl.), S243 (2019).

    Article  Google Scholar 

  5. Nadal, E. et al. Immunotherapy with checkpoint inhibitors in non-small cell lung cancer: insights from long-term survivors. Cancer Immunol. Immunother. 68, 341–352 (2019).

    Article  CAS  Google Scholar 

  6. Gandhi, L. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378, 2078–2092 (2018).

    Article  CAS  Google Scholar 

  7. Socinski, M. A. et al. Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N. Engl. J. Med. 378, 2288–2230 (2018).

    Article  CAS  Google Scholar 

  8. West, H. et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multi-centre, randomised open-label, phase 3 trial. Lancet Oncol. 20, 924–937 (2019).

    Article  CAS  Google Scholar 

  9. Paz-ares, L. et al. Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N. Engl. J. Med. 379, 2040–2051 (2018).

    Article  CAS  Google Scholar 

  10. Hellman, M. D. et al. Nivolumab plus ipilimumab in advanced non-small-cell lung cancer. N. Engl. J. Med. 381, 2020–2031 (2019).

    Article  Google Scholar 

  11. Hodi, F. S. et al. Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial. Lancet Oncol. 19, 1480–1492 (2018).

    Article  CAS  Google Scholar 

  12. Brahmer, J. et al. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC). J. Immunother. Cancer 6, 75 (2018).

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank Scott Gettinger, Philip Grover, Mario Sznol and Yang Zhou for their input into the manuscript.

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Authors and Affiliations

  1. Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA

    Anne C. Chiang & Roy S. Herbst

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  1. Anne C. Chiang
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Correspondence to Roy S. Herbst.

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Competing interests

R.S.H. has received honoraria for consultancy from Abbvie Pharmaceuticals, ARMO Biosciences, AstraZeneca, Biodesix, Bolt Biotherapeutics, Bristol-Myers Squibb, Eli Lilly, EMD Serrano, Genentech/Roche, Genmab, Halozyme, Heat Biologics, IMAB Biopharma, Immunocore, Infinity Pharmaceuticals, Loxo Oncology, Merck and Company, Midas Health Analytics, Nektar, Neon Therapeutics, NextCure, Novartis, Pfizer, Sanofi, Seattle Genetics, Shire PLC, Spectrum Pharmaceuticals, Symphogen, Takeda, Tesaro, and Tocagen. R.S.H. has also received research support from AstraZeneca, Eli Lilly and Merck, and is a member of the board of directors (non-executive/ independent) for Junshi Pharmaceuticals. A.C.C. has received honoraria for consultancy or participation on advisory boards from Abbvie Pharmaceuticals, AstraZeneca, Boehringer-Ingelheim, Bristol-Myers Squibb and Genentech/Roche. A.C.C. has also received research support from AbbVIe Pharmaceuticals, Amgen, AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Merck.

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Chiang, A.C., Herbst, R.S. Frontline immunotherapy for NSCLC — the tale of the tail. Nat Rev Clin Oncol 17, 73–74 (2020). https://doi.org/10.1038/s41571-019-0317-y

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