Allometric tissue-scale stresses at an implant’s surface trigger pathological foreign-body responses, mediated by the activation of mechanoresponsive myeloid cells, that increase exponentially with body size.
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Theocharidis, G., Veves, A. Greater foreign-body responses to big implants. Nat. Biomed. Eng 7, 1340–1342 (2023). https://doi.org/10.1038/s41551-023-01118-x
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DOI: https://doi.org/10.1038/s41551-023-01118-x