The activation-deactivation cycles of G proteins underlie their key roles as molecular switches for a vast array of biological responses. A study in this issue obtains a first look at how G protein–coupled receptors activate heterotrimeric G proteins to switch on signaling pathways by inducing a specific conformational change within their α subunits.
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References
Oldham, W.M. et al. Nat. Struct. Mol. Biol. 13, 772–777 (2006).
Bourne, H.R. Curr. Opin. Cell Biol. 9, 134–142 (1997).
Hamm, H.E. et al. Science 241, 832–835 (1988).
Schwindinger, W.F., Miric, A., Zimmerman, D. & Levine, M.A.A. J. Biol. Chem. 269, 25387–25391 (1994).
Garcia, P.D., Onrust, R., Bell, S.M., Sakmar, T.P. & Bourne, H.R. EMBO J. 14, 4460–4469 (1995).
Natochin, M., Moussaif, M. & Artemyev, N.O. J. Neurochem. 77, 202–210 (2001).
Thomas, T.C., Schmidt, C.J. & Neer, E.J. Proc. Natl. Acad. Sci. USA 90, 10295–10298 (1993).
Posner, B.A., Mixon, M.B., Wall, M.A., Sprang, S.R. & Gilman, A.G. J. Biol. Chem. 273, 21752–21758 (1998).
Marin, E.P., Krishna, A.G. & Sakmar, T.P. J. Biol. Chem. 276, 27400–27405 (2001).
Ceruso, M.A., Periole, X. & Weinstein, H. J. Mol. Biol. 338, 469–481 (2004).
Vetter, I. & Wittinghofer, A. Science 294, 1299–1304 (2001).
Sprang, S.R. Annu. Rev. Biochem. 66, 639–678 (1997).
Noel, J.P., Hamm, H.E. & Sigler, P.B. Nature 366, 654–663 (1993).
Lambright, D.G., Noel, J.P., Ham, H.E. & Sigler, P.B. Nature 369, 621–628 (1994).
Sondek, J., Bohm, A., Lambright, D.G., Hamm, H.E. & Sigler, P.B. Nature 379, 369–374 (1996).
Majumdar, S., Ramachandran, S. & Cerione, R.A. J. Biol. Chem. 279, 40137–40145 (2004).
Cherfils, J. & Chabre, M. Trends Biochem. Sci. 28, 13–17 (2003).
Iiri, T., Farfel, Z. & Bourne, H.R. Nature 394, 35–38 (1998).
Fotiadis, D. et al. Nature 421, 127–128 (2003).
Jastrzebska, B. et al. J. Biol. Chem. 279, 54663–54675 (2004).
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Ramachandran, S., Cerione, R. How GPCRs hit the switch. Nat Struct Mol Biol 13, 756–757 (2006). https://doi.org/10.1038/nsmb0906-756
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DOI: https://doi.org/10.1038/nsmb0906-756
